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Haihua LU, Ph.D.
The Laboratory of Natural Product Synthesis
“Pursuing efficient complex molecule synthesis to appreciate the very beauty of nature, has been and will always be one of the most a(ttra)ctive research area of chemical science, and the focus of my future career. On this exciting path, new reaction methodologies will undoubtedly be explored and developed; while meeting brilliant collaborators to make discoveries to understand biological pathways and finally benefit people, will sure make this journey much more exhilarating.”
Biography
LU Haihua, PI, earned his Ph.D. in 2010 with Professor Wen-Jing Xiao at the Central China Normal University (CCNU), investigating organocatalysis, after which he had an experience in pharmaceutical industry for one and a half years. He then continued his studies as a postdoctoral associate on natural product chemistry with Professor Markus Kalesse at the Leibniz Universität Hannover (LUH), supported by the Alexander von Humboldt foundation (AvH, 2012-2014), and later with Professor Ryan Shenvi at The Scripps Research Institute (TSRI, 2014-2016). He started his independent career at NJTECH University (IAS) in 2016 and joined the School of Science of Westlake University in March 2019.
Research Interest
Our research interests include: 1) diversity-oriented total synthesis based on natural products as leads for drug development; 2) concise natural product total synthesis. Some of the results (including postdoctoral studies) have been published in peer-reviewed journals, such asNat. Chem.,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,etc.
Representative Publications
1. Lu, H.-H.*; Gan, K.-G.; Ni, F.-Q.; Zhang, Z.; Zhu, Y. Concise Total Synthesis of Salimabromide. J. Am. Chem. Soc.2022, 144, 18778-18783.
2. Cao, M.-Y.; Ma, B.-J.; Gu, Q.-X.; Fu, B.; Lu, H.-H.* Concise Enantioselective Total Synthesis of Daphenylline Enabled by an Inramolecular Oxidative Dearomatization. J. Am. Chem. Soc.2022, 144, 5750-5755.
3. Cao, M.-Y.; Ma, B.-J.; Lao, Z.-Q.; Wang, H.; Wang, J.; Liu, J.; Xing, K.; Huang, Y.-H.; Gan, K.-J.; Gao, W.; Wang, H.; Hong, X.; Lu, H.-H.* Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation.J. Am. Chem. Soc. 2020, 142, 12039-12045.
4. Lu, H.-H.; Pronin, S.; Antonova-Koch, Y.; Meister, S.; Winzeler, E. A.; Shenvi, R. A.* Synthesis of (+)-7,20-Diisocyanoadociane and Liver Stage Antiplas-modial Activity of the ICT Class. J. Am. Chem. Soc.2016, 138, 7268-7271.
5. Lu, H.-H.; Martinez, M. D.; Shenvi, R. A.* An Eight-step, Gram-Scale Synthesis of (–)-Jiadifenolide. Nat. Chem. 2015, 7, 604-607.
6. Lu, H.-H.; Raja, A.; Franke, R.; Landsberg, D.; Sasse, F.; Kalesse, M.* Syntheses and Biological Evaluation of Paleo-Soraphens. Angew. Chem. Int. Ed.2013, 52, 13549-13552.
7. Lu, H.-H.; Liu, H.; Wu, W.; Wang, X.-F.; Lu, L.-Q.; Xiao, W.-J.* Catalytic Asymmetric Intramolecular Hydroarylations of ω-Aryloxy- and Arylamino Tethered α,β-Unsaturated Aldehydes. Chem. Eur. J.2009, 15, 2742-2746.
8. Lu, H.-H.; Meng, X.-G.; Zhang, F.-G.; Duan, S.-W.; Xiao, W.-J.* Enantioselective Michael Reactions of β, β-Disubstituted Nitroalkenes: A New Approach to β2,2-Amino Acids with Hetero-Quaternary Stereocenters. Org. Lett.2009, 11, 3946-3949.
